Over the past decade, the United States has witnessed alarming increases in rates of sexually transmitted infections (STIs). Efforts at both the national and local level are needed to address the national STI epidemic. The first-ever STI Federal Implementation Plan for the United States was released on June 8, 2023 by Health and Human Services (HHS), outlining actions needed to reduce the STI burden in the U.S. Please join Dr. Kyle Bukowski and Dr. Karen Wendel in a presentation and discussion about the goals and progress indicators of the Federal plan, and recent national and local data from an ongoing U.S. STI epidemiological study.